Welcome to the Diabetes Prevention Program Study Repository!
The Diabetes Prevention Program is funded by the
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
to determine the safety and efficacy of two interventions
(intensive lifestyle and metformin) relative to a control group
(standard lifestyle recommendations) in preventing or delaying
the confirmed development of diabetes. The objective of the
study is to prevent or delay the onset of diabetes among persons at high
risk using interventions designed to improve abnormal glucose
This web site contains study documents
available to the public who are interested in the research
of the Diabetes
Prevention Program (DPP).
National Diabetes Education Program
National Diabetes Education Program Resources
DPP Summary Fact Sheet
May 5, 2010 -
DPP/DPPOS results were used to support Francis S. Collins' NIH
budget request for Fiscal Year 2011 during his presentation to the
Senate Subcommittee on Labor-HHS-Education Appropriations:
"For type 2 diabetes, prevention appears to be the name of the game. This
form of the disease, which accounts for more than 90% of diabetes among
adults, often can be averted or delayed by lifestyle factors. The
NIH-funded Diabetes Prevention Program (DPP) trial showed that one the
most effective ways to lower the risk of type 2 diabetes is through
regular exercise and modest weight loss. There is good reason to believe
that such efforts may lead to a lifetime of health benefits. A recent
follow-up study of DPP participants found the protective effects of
weight loss and exercise persist for at least a decade. The United Health
Group has recently announced a partnership with Walgreen's and the YMCA
to implement the results of this groundbreaking NIH-funded research on a
here to view the full testimony.
March 24, 2010 -
DPP is mentioned in a
Washington Post interview
with NIH Director, Francis S. Collins.
October 29, 2009 -
The DPPOS showed that during 10-year follow-up after DPP, incidences
in the former placebo and metformin groups fell to equal those in the
former lifestyle group, but the cumulative incidence of diabetes
remained lowest in the lifestyle group. Prevention or delay of
diabetes with lifestyle intervention or metformin can persist for at
least 10 years. For more details, consult the manuscript published in
For more information about the DPP/DPPOS results, go to the
NIDDK Q&A page.
September 28, 2009 -
New American Recovery and Reinvestment Act (ARRA) funds have been
awarded to provide translational and function characterization of
the DPP cohort by genotyping all of the established variants for
relevant metabolic phenotypes; to measure relevant biomarkers around
the time of diabetes onset; to increase time and effort on analyses
to accelerate publications; and to address health economic analyses.
Click here to view more details.
September 11, 2009 -
DPP results mentioned during an
NPR Science Friday interview with Francis S. Collins.
January 12, 2006 -
The DPP data set is now available on the
April 3, 2002 -
Lifestyle Manuals are now available to the public.
March 8, 2002 -
DPP slide set is now available to the public.
February 7, 2002 -
The DPP showed that lifestyle changes and treatment with metformin
both reduced the incidence of diabetes in persons at high risk.
The lifestyle intervention was more effective than metformin.
For more details, consult the manuscript published
New England Journal of Medicine.
February 6, 2002 -
HHS news release describing DPP results:
Diet and Exercise Delay Diabetes and Normalize Blood Glucose.
The site is maintained by the DPP Coordinating Center,
The George Washington University