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Welcome to the Diabetes Prevention Program Study Repository!

The Diabetes Prevention Program is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to determine the safety and efficacy of two interventions (intensive lifestyle and metformin) relative to a control group (standard lifestyle recommendations) in preventing or delaying the confirmed development of diabetes. The objective of the study is to prevent or delay the onset of diabetes among persons at high risk using interventions designed to improve abnormal glucose metabolism.

This web site contains study documents available to the public who are interested in the research aspects of the Diabetes Prevention Program (DPP).

National Diabetes Education Program http://ndep.nih.gov/

National Diabetes Education Program Resources http://ndep.nih.gov/resources/index.aspx/

DPP Summary Fact Sheet http://diabetes.niddk.nih.gov/dm/pubs/preventionprogram/index.htm

Latest News

May 5, 2010 - DPP/DPPOS results were used to support Francis S. Collins' NIH budget request for Fiscal Year 2011 during his presentation to the Senate Subcommittee on Labor-HHS-Education Appropriations:

"For type 2 diabetes, prevention appears to be the name of the game. This form of the disease, which accounts for more than 90% of diabetes among adults, often can be averted or delayed by lifestyle factors. The NIH-funded Diabetes Prevention Program (DPP) trial showed that one the most effective ways to lower the risk of type 2 diabetes is through regular exercise and modest weight loss. There is good reason to believe that such efforts may lead to a lifetime of health benefits. A recent follow-up study of DPP participants found the protective effects of weight loss and exercise persist for at least a decade. The United Health Group has recently announced a partnership with Walgreen's and the YMCA to implement the results of this groundbreaking NIH-funded research on a broad scale."

Click here to view the full testimony.

March 24, 2010 - DPP is mentioned in a Washington Post interview with NIH Director, Francis S. Collins.

October 29, 2009 - The DPPOS showed that during 10-year follow-up after DPP, incidences in the former placebo and metformin groups fell to equal those in the former lifestyle group, but the cumulative incidence of diabetes remained lowest in the lifestyle group. Prevention or delay of diabetes with lifestyle intervention or metformin can persist for at least 10 years. For more details, consult the manuscript published in The Lancet.

For more information about the DPP/DPPOS results, go to the NIDDK Q&A page.

September 28, 2009 - New American Recovery and Reinvestment Act (ARRA) funds have been awarded to provide translational and function characterization of the DPP cohort by genotyping all of the established variants for relevant metabolic phenotypes; to measure relevant biomarkers around the time of diabetes onset; to increase time and effort on analyses to accelerate publications; and to address health economic analyses.

Click here to view more details.

September 11, 2009 - DPP results mentioned during an NPR Science Friday interview with Francis S. Collins.

January 12, 2006 - The DPP data set is now available on the NIDDK repository.

April 3, 2002 - The Lifestyle Manuals are now available to the public.

March 8, 2002 - The DPP slide set is now available to the public.

February 7, 2002 - The DPP showed that lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin. For more details, consult the manuscript published in the New England Journal of Medicine.

February 6, 2002 - HHS news release describing DPP results: Diet and Exercise Delay Diabetes and Normalize Blood Glucose.



The site is maintained by the DPP Coordinating Center, The George Washington University Biostatistics Center.