National Institute of Child Health and Human Development
Maternal-Fetal Medicine Units Network

Research Projects

The MFMU Network has completed more than 36 studies. More than 159 papers resulting from research projects have been published or accepted for publication as of February 2009, and more than 324 presentations of results have been made.

SCAN Trial

• A Randomized Trial of 17 Alpha-Hydroxyprogesterone Caproate (17P) for Prevention of Preterm Birth in Nulliparous Women with a Short Cervix

TSH Trial

• A Randomized Trial of Thyroxine Therapy for Subclinical Hypothyroidism or Hypothyroxinemia Diagnosed During Pregnancy

CAPPS Trial

• Combined Antioxidant and Preeclampsia Prediction Studies

GDM Trial

• A Randomized Trial of Treatment for Mild Gestational Diabetes Mellitus

Beam Trial

• Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate

Omega-3 Trial

• Randomized Clinical Trial of Omega-3 Supplementation To Prevent Preterm Birth

FOX Trial

• Clinical Trial of Fetal Pulse Oximetry

Progesterone
Follow-Up

• Follow-up study of the children from the 17-Alpha Hydroxyprogesterone Caproate Trial

STTARS Trial

• A Randomized Study of Seventeen Alpha-Hydroxyprogesterone Caproate in Twins and Triplets

STEROIDS Trial

• Trial of Antenatal Corticosteroid Regimens

ASTHMA Trial

• Randomized Clinical Trial of Theophylline Versus Inhaled Beclomethasone in the Treatment of Moderate Asthma During Pregnancy


• Ancillary: Asthma Quality of Life Study

ASTHMA Cohort Study

• An Observational Cohort Study to Evaluate the Effects of Asthma and Treatment Regimens on Perinatal Outcome

BV/TV

• Pilot: A Comparison of Screening Methods of T. Vaginalis, Bacterial Vaginosis and Candida Sp.


• Trial: Randomized Clinical Trials of Metronidazole to Improve Pregnancy Outcome in Women Infected with T. Vaginalis (TV) and in Women with Bacterial Vaginosis (BV)


• Ancillary: Fetal Fibronectin Cohort

CERVICAL ULTRASOUND Study

• Mid-Trimester Endovaginal Sonography in Women at High Risk for Spontaneous Preterm Delivery

CESAREAN SECTION Registry

• An Observational Study of Cesarean Section and Vaginal Birth after Cesarean Section

FACTOR V LEIDEN Study

• A Prospective Observational Study of Women with Factor V Leiden Mutation in Pregnancy

FFN Trial

• Randomized Clinical Trial of Metronidazole plus Erythromycin to Prevent Preterm Birth in Women with Elevated Cervical/Vaginal Oncofetal Fibronectin (FFN)

HIGH-RISK ASPIRIN Trial

• Randomized Clinical Trial of Low-Dose Aspirin to Prevent Preeclampsia in High-Risk Women


• Ancillary: Serum Thromboxane Ancillary Study

HUAM Cohorts Study

• Assessment of Home Uterine Activity Monitoring (HUAM) for the Prediction of Preterm Labor/Delivery


• Ancillaries:
  • Psychosocial Questionnaire Study
  • Enzyme Analysis Ancillary Study
  
  

LOW-RISK ASPIRIN Trial

• Randomized Clinical Trial of Low-Dose Aspirin (60mg) as a Preventative of Preeclampsia

ODNS Registry

• Obstetrical Determinants of Neonatal Survival (ODNS)

PRETERM LABOR Trial

• Randomized Clinical Trial of Adjunctive Antibiotic Treatment in Preterm Labor with Intact Membranes

PRETERM PREDICTION Cohorts

• Screening for Risk Factors for Spontaneous Preterm Delivery in Singletons and Twins


• Ancillary: Psychosocial Questionnaire Study

PRETERM PROM Trial

• Randomized Clinical Trial of Adjunctive Antibiotic Treatment with Preterm Premature Rupture of Membranes


• Ancillary: Placenta Pathology Study

POST TERM Trial

• Randomized Clinical Trial of Induction Versus Expectant Management in Postterm Pregnancy

PROGESTERONE Trial

• Randomized Trial of 17 a-Hydroxyprogesterone (17P) for Prevention of Preterm Birth in High Risk Women

'STUCK-TWIN' Trial

• Randomized Clinical Trial of Therapeutic Amniocentesis for Management of 'Stuck-Twin' Phenomenon

VZV Registry

• Registry of Maternal Varicella-Zoster Virus Infections in Pregnancy

GENERAL & REVIEW

• Assorted MFMU Presentations and Publications