|Research Staff |
John M. Lachin, Sc.D.
Research Professor of Biostatistics and Epidemiology, and Statistics
The Biostatistics Center of The George Washington University
6110 Executive Blvd.
Rockville MD 20852
Dr. Lachin is Research Professor of Biostatistics and Epidemiology, and of Statistics, formerly with tenure 1987-2014; and formerly served as Director of The Biostatistics Center , a major research facility, 1998-2000.
Dr. Lachin was born and raised in New Orleans, Louisiana; received his B.S. in experimental psychology from Tulane University in 1965, and his Sc.D. in biostatistics from the University of Pittsburgh in 1972. In 1973 Dr. Lachin joined George Washington University as Assistant Research Professor of Statistics at The Biostatistics Center. He was promoted to Associate Research Professor in 1977 and Research Professor in 1982. In 1984 he was appointed Professor of Statistics, and tenure was awarded in 1987. In 2000 his appointment was shifted to the newly established School of Public Health and Health Services, now the Milken Institute School of Public Health.
Dr. Lachin served as Assistant Director of The Biostatistics Center from 1980-1985, as Co-Director from 1985-1988, Director from 1988-2000, and again as Co-Director from 2000-2010, and Interim Director from 2010-2012. The Center is the largest research program in the University with a staff of 115 and funding exceeding $60 million annually.
Dr. Lachin is currently the Principal Investigator of the Coordinating Center for the Epidemiology Of Diabetes Interventions And Complications (EDIC) study, and The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), with total funding for the current 5 year interval of $148 million. He is also Co-Investigator for the Diabetes Prevention Program Outcomes Study (DPPOS). Previously, he directed the biostatistical coordinating centers for the NIH funded Type 1 Diabetes TrialNet Coordinating Center (TrialNet) (2001-2008), the Diabetes Control and Complications Trial (DCCT) (1981-1998), the Study of Plasmapheresis in Severe Lupus Nephritis (1981-1988), and the National Cooperative Gallstone Study (1980-1984), among others. He was also the initial co-PI for the Angiotensin Converting Enzyme Inhibition (ACEi) with Captopril in Diabetic Nephropathy, and established "doubling of serum creatinine" as an outcome in numerous treatment trials for nephropathy. All of this research was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The Diabetes Control and Complications Trial Research Group was awarded the Charles H. Best Medal in 1994 by the American Diabetes Association for "Distinguished Service in the Cause of Diabetes."
Dr. Lachin led the development of the GWU graduate programs in Biostatistics and Epidemiology; and served as Director of the Program from its inception in 1995 until July, 2004. Dr. Lachin introduced 4 new graduate courses into the University curriculum: Data Analysis (Statistics 6210); Design of Medical Studies (formerly Statistics 224, now PH 6247); Biostatistical Methods (formerly Statistics 225, now HP 6266); and Survival Analysis (Statistics 6227). He has directed or co-directed the PhD doctoral dissertation research of 15 students in Statistics, Biostatistics or Epidemiology. Dr. Lachin is no longer teaching but continues supervise doctoral student dissertation research.
Dr. Lachin is the co-author of the graduate reference text, with W. Rosenberger, Randomization in Clinical Trials: Theory and Practice, John Wiley and Sons, 2002 that received the American Association of Publishers award for "The Professional and Scholarly Title of 2002 In Mathematics and Statistics." He is also the author of the graduate reference text Biostatistical Methods (2nd Edition), The Assessment of Relative Risks, John Wiley and Sons; Second Edition, 2011, First Edition 2000; and a co-editor of the book The Randomized Clinical Trial and Therapeutic Decisions, Marcel-Dekker, 1982.
As of January 2015, Dr. Lachin is a named or contributing author of 286 peer-reviewed publications, 59 of which concern statistical and research methodology; and 227 the results of medical investigations. His publications include 15 papers in The New England Journal of Medicine as a named author or member of the writing team, one as the Chair of the writing team (first author). He also authored 20 book sections and non-refereed publications. As of April 15, 2015 his h-index was 60, meaning that 60 of his peer reviewed authored papers had been cited at least 60 times. His i10 Index was 136 and his papers had received 21,373 citations.
Dr. Lachin're recent methodological publications include papers on the Wei-Lachin multivariate one-directional test for multiple outcomes, the evaluation of sample size and power for survival analyses with multiple groups, strata and quantitative covariates in a Cox Proportional Hazards regression model, sample size and power for statistical tests for discrete and grouped event time data, and sample size and power for tests applied to ordinal data.
His recent co-authored medical papers include the demonstration that intensive treatment of type 1 diabetes leading to near normal levels of glucose during the DCCT can reduce mortality and the progression or retinal and renal microvascular complications during the DCCT/EDIC study, the phenomenon of metabolic memory that was first reported in a landmark paper in the New England Joural of Medicine in 2000 for which Dr. Lachin was the lead author. He also contributed to describing the effects of weight loss and other factors that reduce the risk of developing type 2 diabetes when treated with a lifestyle intervention or the agent metformin during the DPP. He is now also the co-PI of the GRADE study to evaluate the long term effects of different agents for initial treatment of Type 2 diabetes.
In addition to his NIH-funded research, he has collaborated with industry as an adviser and consultant to therapeutic studies of type 1 and 2 diabetes, cardiovascular outcome trials of type 2 diabetes therapies and renal disease in type 2 diabetes, among many other indications.
Dr. Lachin is a member of 13 societies that include every major national or international society in statistics/biostatistics/clinical trials and diabetes. He has been elected a Fellow of the Society for Clinical Trials, the American Statistical Association and the Royal Statistical Society, and a member of the International Statistical Institute. He has held offices in various societies and was President of the Society for Clinical Trials for 2002-2003. He has lectured widely on his research on Diabetes and his statistical methodological research at meetings of the American Diabetes Association, the congress of the World Diabetes Congress of the International Diabetes Federation (IDF), the European Association for the Study of Diabetes, the American Statistical Association, the International Biometrics Society and the Society for Clinical Trials; and at workshops and symposia organized by the National Institutes of Health, the Juvenile Diabetes Association, and the National Academy of Sciences, among many venues.
Updated August 2015
Biostatistical Methods (First Edition): The Assessment of Relative Risks
Biostatistical Methods (2nd Edition): The Assessment of Relative Risks
Course Materials -- Statistics 210
Materials Available for Download