COLLABORATIVE STUDY OF THE TREATMENT OF LACTIC ACIDOSIS WITH DICHLOROACETAT (TLAD)
Principal Investigator: Elizabeth C. Wright, Ph.D
The Collaborative Study of the Treatment of Lactic Acidosis with Dichloroacetat was a randomized, controlled, multicenter study of 252 patients at 8 centers to evaluate the effectiveness of DCA in the treatment of acute lactic acidosis. The study showed that DCA had some beneficial effects on the acute biochemical imbalance but failed to improve survival (NEJM, 1992).
NIH/NIDDK Grant R01-AM-35448, 1986-1992)