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Principal Investigator:  Sarah E. Fowler, Ph.D.
Co-Investigator:  Kathryn Hirst, Ph.D.

The Biostatistics Center served as coordinating center for the Dysfunctional Uterine Bleeding Intervention Trial (DUBIT), funded by the Agency for Healthcare Research and Quality (AHRQ). Dysfunctional uterine bleeding can be simply defined as abnormal uterine bleeding that occurs in the absence of systemic or reproductive organ disease. DUBIT offers eligible women a choice of three treatment regimens: hysterectomy, endometrial ablation, or medical management with gonadotropin releasing hormone agonist (GnRH) followed by oral contraceptives. The primary objective of DUBIT is to compare the three treatments on control of bleeding, satisfaction, and health related quality of life.

Funded by the HHS/AHRQ U01-HS09502A- 02, Cooperative Agreement, 1999.)