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ASSOCIATION OF COMMON ALLELES WITH LONG-TERM DIABETIC COMPLICATIONS

Principal Investigator:  Patricia A. Cleary, M.S.

 
The Biostatistics Center (BSC) provides data analysis for the Genome-Wide Association Study for Type I Diabetes Complications, which is funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to the Hospital for Sick Children, Toronto. This large-scale study uses samples from Epidemiology Of Diabetes Interventions And Complications (EDIC) and Genetics Of Kidneys In Diabetes (GoKinD) studies to identify genes and specific genetic variants that confer susceptibility or resistance to diabetic complications. The BSC performs descriptive analysis of 500,000 single nucleotide polymorphisms (SNPS) in GoKinD cases and controls; quality control analysis; analysis of 500,000 SNPS with renal outcomes in GoKinD probands, including analysis with covarites. The BSC cleans genotype data from relatives and performs family-based analysis of about 25k SNPS of association with case and control status in GoKinD, including analysis of hapoltypes.

Funded by the NIH/NIDDK Grant 1-R01DK077510-01, 2006-2009.)