EPIGENOMIC APPROACHES TO EVALUATE METABOLIC MEMORY IN THE EDIC COHORT (EPIGENETICS)
Principal Investigator: Patricia A. Cleary, M.S.
Epigenetics is the study of heritable changes in gene function without a local change in DNA sequence. The central hypothesis is that, apart from genetic changes, epigenetics and the associated chromatin changes also play significant roles in the etiology of T1D and its complications. We postulate that persistent key chromatin for the sustained dysregulated gene express, and that the abnormal gene expression pattern causes the heightened diabetes complications rates observed in the [[EDI]] (EDIC) cohort that were shifted from conventional to intensive therapy.
Funded by Juvenile Diabetes Research Foundation grant # 17-2008-900 (2008-2011).)