LIPOPROTEINS AND PEDF IN THE VASCULAR COMPLICATIONS OF DIABETES (LIPOPROTEINS)
Principal Investigator: Patricia A. Cleary, M.S.
Co-Investigator: John M. Lachin, Sc.D.
The Biostatistics Center EDIC staff under the direction of Patricia Cleary have forwarded to the University of Oklahoma the macro and microvascular complications data collected during 27 years of DCCT and EDIC. In addition the EDIC biostatisticians will help interpret the analyses and will participate in manuscript preparation. The Biostatistics Center provides data for this project designed to study micro- and macrovascular disease, major causes of morbidity and premature mortality in diabetes mellitus. The underlying hypothesis is that vascular damage is promoted by the inter-related processes of dyslipoproteinemia, inflammation, and oxidative stress, which may in part be mediated by growth factor imbalance. The project utilizes data and specimens collected and analyzed by the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Group, the Veterans Affairs Diabetes Trial (VADT) Study Group, and investigators at the Medical University of South Carolina and the University of Oklahoma Health Sciences Center. First, the study will define the role of lipoprotein subclasses defined by nuclear magnetic resonance (NMR) as markers for macro- and microvascular complications of diabetes. Lipoprotein subclasses will be related cross-sectionally and longitudinally to complication status, and to existent (concurrent) data of detailed measures of dyslipoproteinemia, inflammation, oxidative stress, and other measures of endothelial dysfunction and insulin resistance. Second, the study will define associations and possible pathogenic role of circulating Pigment Epithelial Derived Factor (PEDF) in the vascular complications of diabetes. PEDF, which has anti-inflammatory, anti-oxidant and anti-angiogenic actions is implicated (as a protective factor) in diabetic retinopathy and nephropathy, but may have different actions and significance in atherosclerosis. The eventual goal is an understanding of vascular damage in diabetes that will result in better predictive and therapeutic strategies. Funding by NIDDK (Grant 1R01DK080043-01A2) through a subagreement with the University of Oklahoma Health Sciences Center, 2009 – 2011.)