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he Biostatistics Center provides data management and analysis for this project which is designed to establish a centralized genetics strategy in DPP/DPPOS, in order 1) to coordinate genetic analyses so that unnecessarily redundant and wasteful studies would not be performed; 2) assure high quality analyses; and 3) carry out the genetic studies mandated in the DPP protocol. The aims of the Genetics Core are: 1) to determine whether common or rare variation in five genes associated with mature onset diabetes predicts the development of type 2 diabetes in the DPP cohort; 2) to determine whether common variation in genes that encode hypoglycemic drug targets predicts rate of development of type 2 diabetes in the DPP participants; 3) to determine whether common variation in mitochondrial and other genes implicated in insulin resistance, beta cell function, exercise, obesity and energy utilization predict development of type 2 diabetes in the DPP cohort, and whether risk is altered in subjects treated with a lifestyle intervention, metformin or troglitazone; and 4) to enable other investigators interested in testing genetic hypotheses in the DPP. Funding by NIDDK (R01-DK072041-01), through a subcontract with Massachusetts General Hospital, 2005-2010.