Co-Investigator: Kathryn Hirst, Ph.D.

he Biostatistics Center serves as coordinating center for the Dysfunctional Uterine Bleeding Intervention Trial (DUBIT), funded by the Agency for Health Care Policy and Research. Dysfunctional uterine bleeding can be simply defined as abnormal uterine bleeding that occurs in the absence of systemic or reproductive organ disease. DUBIT offers eligible women a choice of three treatment regimens: hysterectomy, endometrial ablation, or medical management with gonadotropin releasing hormone agonist (GnRH) followed by oral contraceptives. The primary objective of DUBIT is to compare the three treatments on control of bleeding, satisfaction, and health related quality of life. The three clinical centers and the coordinating center are presently engaged in data analysis, report, and closeout of DUBIT. Funded by the Agency for Health Care Policy and Research U01-HS09502A- 02, Cooperative Agreement, 1999.