Co-Principal Investigator: Joel I. Verter, Ph.D.

  cross-sectional screening and prospective cohort study to evaluate the relationship between maternal use of cocaine and/or opiates during pregnancy and the incidence of acute neonatal complications and long-term neurodevelopmental outcome of both premature and full-term infants. Based on results of screening over 19,000 mothers for in-utero exposure to cocaine/opiate by meconium and maternal self-report in 4 clinical centers, 658 infants, and their mothers, positive for in-utero exposure and 742 matched controls, have been enrolled in a 3-year neurobehavioral, neurodevelopmental and environmental follow-up evaluation. The EMLI study was sponsored by the NICHD, the Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse (ADAMHA-NIDA), Center for Substance Abuse Treatment (ADAMHA-CSAT) and the Office of Human Development Services Administration for Children, Youth and Families (ACYF). NICHD Cooperative Agreement 5-U01-HD-19897, 1992-1998.