Principal Investigator: Naji Younes, Ph.D.

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his study is a randomized, controlled, factorial clinical trial to evaluate the use of selected interventions in reducing the progression of coronary atherosclerosis in women. Approximately four hundred-twenty eligible women will be randomized into the clinical trial. The trial will utilize a factorial design to test the effect of a regimen of hormonal replacement therapy (an estrogen, and a progestin, when appropriate) and a combination of the antioxidants vitamins C and E, on the progression of atherosclerotic lesions in the coronary arteries. To accomplish this a multi-disciplined team of investigators from 7 Clinical Centers, a Statistical Coordinating Center (SCC), the National Heart, Lung and Blood Institute (NHLBI) project office, one central serum chemistry laboratory, a central angiographic reading center and a central pharmacy have been assembled. Contract funded by NHLBI, N01-HV-68165, 1996- 2001.