National Institute of Child Health and Human Development
Maternal Fetal Medicine Units Network

Publications & Presentations
High Risk Asprin RCT

Publications

1. Caritis S, Sibai B, Hauth J, Lindheimer M, Klebanoff M, Thom E, VanDorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G, for the NICHD MFMU Network. Low dose aspirin to prevent preeclampisa in women at high risk. New England Journal of Medicine, 38(11): 701-705, 1998.



2. Hauth J, Sibai B, Caritis S, VanDorsten P, Lindheimer M, Klebanoff M, MacPherson C, Landon M, Paul R, Miodovnik M, Meis P, Dombrowski M, Thurnau G, Walsh S, McNellis D Roberts JM, for the NICHD MFMU Network. Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high risk pregnancies in a low-dose aspirin trial. American Journal of Obstetrics & Gynecology, 179(5): 1193-1199, 1998.



3. Caritis S, Sibai B, Hauth J, Lindheimer M, Klebanoff M, Thom E, VanDorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G, Dombrowski M, McNellis D, Roberts J and the NICHD MFMU Network. Predictors of preeclampsia in high risk women. American Journal of Obstetrics & Gynecology, 179(4): 946-951, 1998.



4. Sibai B, Lindheimer M, Hauth J, Caritis S, Klebanoff M, MacPherson C, VanDorsten P, Landon M, PaulR, Miodovnik M, Meis P. Dombrowksi M and the NICHD MFMU Network. Risk factors for preeclampsia,abruptio, adverse neonatal outcome in women with chronic hypertension. New England Journal of Medicine, 339: 667-671, 1998.



5. Hogg B, Hauth J, Caritis S, Sibai, BM, Lindheimer M, VanDorsten P, Klebanoff M, MacPerson C, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G, Roberts J and McNellis D for the NICHD MFMU Network. Safety of labor epidural anesthesia in women with severe hypertensive disease. American Journal of Obstetrics & Gynecology, 181(5): 1096-1101, 1999.



6. Sibai BM, Caritis S, Hauth J, Lindheimer M, VanDorsten P, MacPherson C, Klebanoff M, Landon M, Miodovnik M, Paul R, Meis P, Dombrowski M, Turnau G, Roberts J and McNellis D for the NICHD MFMU Network. Risk of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. American Journal of Obstetrics & Gynecology, 182(2): 364-370, 2000.



7. Sibai BM, Hauth J, Caritis S, Lindeimer MD, MacPerson C, Klebanoff M, VanDorsten JP, Landon M, Miodovnik M, Paul R, Meis P, Thurnau G, Dombrowski M, Roberts J, McNellis D, for the NICHD MFMU Network. Hypertensive disorders in twin vs. singleton gestations. American Journal of Obstetrics & Gynecology, 182(4): 938-942, 2000.



8. Sibai B, Caritis S, Hauth J, MacPherson C, Van Dorsten J, Klebanoff M, Landon M, Paul R, Meis P, Midovnik M, Dombrowski M, Thurnau G, Moawad A, Roberts J for the NICHD MFMU Network. Preterm delivery in women with pregestational diabetes milletus or chronic hypertension relative to women with uncomplicated pregnancies. American Journal of Obstetrics & Gynecology, 183(6): 1520-1524, 2000.



9. Branch DW, Porter TF, Rittenhouse L, Caritis S, Sibai B, Hauth J, Lindheimer MD, Klebanoff M, MacPherson C, VanDorsten P, Landon M, Paul R, Miodovnik M, Meis PJ, Thurnau G for the NICHD MFMU Network. Antiphospholipid antibodies in women at risk for preeclampsia. American Journal of Obstetrics & Gynecology, 184(5): 825-834, 2001.



10. Bucchbinder A, Sibai B, Caritis S, MacPherson C, Hauth J, Lindheimer M, Klebanoff M, VanDorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G for the NICHD MFMU Network. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. American Journal of Obstetrics & Gynecology, 186(1): 66-71, 2002.



11. Hnat MD, Sibai BM, Caritis S, Hauth J, Lindheimer MD, MacPherson C, VanDorsten JP, Landon M, Miodovnik M, Paul R, Meis P, Thurnau G, Dombrowski M. for the NICHD MFMU Network. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. American Journal of Obstetrics & Gynecology, 186(3): 422-6, 2002.



12. How H, Sibai B, Lindheimer M, Caritis S, Hauth J, Klebanoff M, MacPherson C, Van Dorsten P, Miodovnik M, Landon M, Paul R, Meis P, Thurnau G, Dombrowski M, Roberts J. Is early-pregnancy proteinuria associated with an increased rate of preeclampsia in women with pregestational diabetes mellitus? American Journal of Obstetrics & Gynecology, 190(3): 775-778, 2004.

Presentations

1. Caritis S, for the NICHD MFMU Network. Low dose aspirin does not prevent preeclampsia in high risk women. Presented at the 17th Annual Meeting of the Society of Perinatal Obstetricians, Anaheim, CA, January 1997.



2. Hauth JC, for the NICHD MFMU Network. Safety of low-dose aspirin in high risk patients. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



3. Hauth JC, for the NICHD MFMU Network. Maternal serum thromboxane B2 reduction did not predict improved pregnancy outcome in high risk women in a low dose aspirin trial. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



4. Hauth JC, for the NICHD MFMU Network. Adverse maternal, fetal and neonatal outcomes in women in a low-dose aspirin trial who developed preeclampsia. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



5. Sibai BM, for the NICHD MFMU Network. Risk factors for adverse pregnancy outcome in women with chronic hypertension. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



6. Caritis SN, for the NICHD MFMU Network. Impact of preeclampsia on a subsequent pregnancy. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



7. Caritis SN, for the NICHD MFMU Network. Predictors of preeclampsia in high risk women. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



8. Hogg B, for the NICHD MFMU Network. Safety of a labor epidural in women wiht evere preeclampsia (PE) or severe pregnancy induced hypertension (PIH). Presented at the 19th Annual Meeting of the Society of Maternal-Fetal Medicine, San Francisco, CA, January 1999.



9. Sibai B, for the NICHD MFMU Network. Risk factors for preeclampsia and adverse neonatal outcomes in women with preexisting diabetes Mellitus.Presented at the 19th Annual Meeting of the Society of Maternal-Fetal Medicine, San Francisco, CA, January 1999.



10. Rosen B, for the NICHD MFMU Network. What are the odds against the second twin? Presented at the 19th Annual Meeting of the Society of Maternal-Fetal Medicine, San Francisco, CA, January 1999.



11. Newman R, for the NICHD MFMU Network. Increased maternal weight gain in twins improved perinatal outcome. Presented at the 19th Annual Meeting of the Society of Maternal-Fetal Medicine, San Francisco, CA, January 1999.



12. Thom E, for the NICHD MFMU Network. Comparison of central vs. local review of cranial ultrasound in a multicenter trial. Presented at the 20th Annual Meeting of the Society for Clinical Trials, Anaheim, CA, May 1999.



13. Sibai B, for the NICHD MFMU Network. Hypertensive disorder in twin versus singleton pregnancies. Presented at the 20th Annual Meeting of the Society of Maternal-Fetal Medicine, Miami, FL, February 2000.



14. How H, for the NICHD MFMU Network. Is "incipient nephropathy" associated with an increased rate of preeclampsia in women with pregestational diabetes? Presented at the 20th Annual Meeting of the Society of Maternal-Fetal Medicine, Miami, FL, February 2000.



15. Sibai BM, for the NICHD MFMU Network. Preterm delivery in women with chronic hypertension or pregestational diabetes versus normal pregnancy. Presented at the 20th Annual Meeting of the Society of Maternal-Fetal Medicine, Miami, FL, February 2000.



16. Meis PJ, for the NICHD MFMU Network. Does fetal stress cause spontaneous birth? Presented at the 47th Annual Meeting of the Society of Gynecological Investigators, Chicago, IL, March 2000.



17. Branch DW, for the NICHD MFMU Network. Antiphospholipid antibodies in women at risk for preeclampsia. Presented at the Annual Meeting of the American Gynecological and Obstetrical Society, Williamsburg, VA, September 2000.



18. Sibai B, Romero R, for the NICHD MFMU Network. Changes in the maternal plasma concentrations of two angiogenic factors-placental growth factor and angiogenin-precede the development of preeclampsia. Presented at the 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, CA, March 2001.



19. Sibai B, Romero R, for the NICHD MFMU Network. Plasma concentrations of the soluble tumor necrosis factor receptor 2 are increased prior to the development of preeclampsia. Presented at the 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, CA, March 2001.



20. Lain KY, Caritis S, for the NICHD MFMU Network. Elevated cellular adhesion molecule concentrations in mid-pregnancy may predict recurrent preeclampsia. Presented at the 21st Annual Meeting of the Society for Maternal Fetal Medicine, Reno, NV, February 2001.



21. Hnat M, for the NICHD MFMU Network. Perinatal outcome in women with recurrent preeclampsia compared with those who develop preeclampsia as nulliaparia. Presented at the 21st Annual Meeting of the Society for Maternal Fetal Medicine, reno, NV, February 2001.



22. Myatt L, for the NICHD MFMU Network. Do women at high risk develop preeclampsia earlier in gestation than those at low risk? Presented at the 21st Annual Meeting of the Society for Maternal Fetal Medicine, Reno, NV, February 2001.



23. Hogg B, for the NICHD MFMU Network. The influence of gestational age on the effectiveness of low-dose aspirin for the prevention of hypertensive disease and growth restriction in pregnancy. Presented at the 21st annual meeting of the Society for Maternal Fetal Medicine, Reno, NV, February 2001.



24. Hubel CA and Roberts JM, for the NICHD MFMU Network. Serum ferritin and transferrin saturation are inreased in early gestation in women who subsequently develop preeclampsia with preterm but not term delivery: potential markers of inflammation. Presented at the 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, CA, March 2001.



25. Lain KY and Roberts JM, for the NICHD MFMU Network. The protection of smoking against preeclampsia is lost in older women. Presented at the 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, CA, March 2001.



26. Buchbinder A, for the NICHD MFMU Network. Adverse perinatal outcomes are significantly higher in women with severe gestational hypertension compared with mild preeclampsia. Presented at the 48th Annual Meeting of the Society for Gynecologic Investigation, Toronto, CA, March 2001.



27. Hubel C, for the NICHD MFMU Network. Serum sialic acid is increased in women who subsequently develop preeclampsia with preterm but not term delivery: A marker of inflammation influenced by aspirin? Presented at the 49th Annual Meeting of the Society for Gynecologic Investigation , Los Angeles, CA, March 2002.



28. Laivouri HM and Roberts JM, for the NICHD MFMU Network. Serum leptin concentration is higher in women destined to develop preeclampsia near term. Presented at the 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, March 2002.



29. Lain K, for the NICHD MFMU Network. Vasculur cell adhesion molecule concentrations in mid pregnancy are associated with the development of preeclampsia in women with chronic hypertension. Presented at the 49th Annual Meeting of the Society for Gynecolgic Investigation, Los Angeles, CA, March 2002.



30. Benyo DF, Conrad KP for the NICHD MFMU Network. Circulating levels of interleukin-6 and tumor necrosis factor-a throughout pregnancy in women with a high risk to develop preeclampsia. Presented at the International Society for the Study of Hypertension in Pregnancy, Toronto, Canada, June 2002.



31. Myatt L, for the NIH Maternal Fetal Medicine Network. Differences in the time of diagnosis of Mild vs. severe preeclampsia between low and high risk patient groups. Presented at the International Society for Study in Hypertension in Pregnancy, Toronto, Canada, June 2002.



32. Head B, Hauth J, for the NICHD MFMU Network. Midtrimester cotinine levels and the risk or preclampsia and intrauterine growth restriction. Presented at the 23rd Annual Meeting of the Society for Maternal Fetal Medicine, San Francisco, CA, February 2003.



33. Ramsey P for the NICHD MFMU Network. Are maternal cotinine levels associated with spontaneous preterm birth (SPB) or preterm premature rupture of membranes (PPROM)? Presented at the Society for Gynecologic Investigation, Washington, DC, March 2003.



34. Ramsey P, Hauth J for the NICHD Network and the University of Alabama at Birmingham. Do maternal serum cotinine levels correlate with self-reported smoking behavior during pregnancy? Presented at the 51st Annual Meeting of the American College of Obstetricians and Gynecologists, New Orleans, April 2003.



35. Leuchtenburg L, for the NICHD MFMU Network. Compliance factors among pregnant women in multicenter trials. Presented at the 3rd Joint Meeting of the International Society for Clinical Biostatistics and the Society for Clinical Trials, London, UK, July 2003.



36. Ramsey P and Parker R. Elevated midtrimester maternal serum human chorionic gonadotropin (HCG) levels, but not progesterone or estriol, are associated with the subsequent development of preeclampsia (PRE). Presented at the 24th Annual Meeting of the Society for the Maternal Fetal Medicine, New Orleans, LA, February 2004.



37. Ramsey P and Parker R. Are midtrimester maternal serum levels of endocrine markers associated with the subsequent development of spontaneous preterm birth (SPB)? Presented at the 51st Annual Meeting of the Society for Gynecologic Investigation, Houston, TX, March 2004.



38. Parker R and Ramsey P. Racial differences in midtrimester maternal markers of the feto-placental unit Presented at the 51st Annual Meeting of the Society for Gynecologic Investigation, Houston, TX, March 2004.



39. Ho, M for the NICHD MFMU Network. Clinical markers of adverse perinatal outcomes in women with chronic hypertension. Presented at the Annual Meeting of the Society for Gynecological Investigation, Toronto, Canada, March 2006.



40. Gammill, HS and Powers RW for the NICHD MFMU Network. Does C-reactive protein predict recurrent preeclampsia? Presented at the Annual Meeting of the Society for Gynecological Investigation, Toronto, Canada, March 2006.



41. Powers, RW & Jeyabalan, A for the NICHD MFMU Network. Do differences in antiangiogenic factors precede the development of preeclampsia in high-risk women? Presented at the 54th Annual Scientific Meeting for Society of Gynecologic Investigation, Reno, NV, March 2007.



42. Jeyabalan, A & Powers, RW for the NICHD MFMU Network. Effect of smoking on circulating angiogenic factors in high risk pregnancies. Presented at the 54th Annual Scientific Meeting for Society of Gynecologic Investigation, Reno, NV, March 2007.



43. Roberts, JM for the NICHD MFMU Network. Hyperuricemia without proteinuria is associated with adverse fetal outcomes in women with gestational hypertension. Presented at the 54th Annual Scientific Meeting for Society of Gynecologic Investigation, Reno, NV, March 2007.