National Institute of Child Health and Human Development
Maternal Fetal Medicine Units Network

Publications & Presentations
Preterm PROM Trial (pPROM)

Publications

1. Mercer B, Miodovnik M, Thurnau G, Goldenberg R, Das A, Ramsey R, Rabello Y, Meis P, Moawad A, Iams J, Van Dorsten JP, Paul R, Bottoms S, Merenstein G, Thom E, Roberts J, McNellis D for the NICHD MFMU Network. Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. The Journal of the American Medical Association, 278(12): 989-995, 1997.



2. Goldenberg RL, Mercer B, Miodovnik M, Thurnau G, Meis P, Moawad A, Paul R, Bottoms S, Das A, Roberts J, McNellis D, and Tamura T for the NICHD MFMU Network. Plasma ferritin, premature rupture of membranes and pregnancy outcome. American Journal of Obstetrics & Gynecology, 179(6): 1599-1604, 1998.



3. Alexander JM, Mercer BM, Miodovnik M, Thurnau GR, Goldenberg RL, Das AF, Meis PJ, Moawad AH, Iams JD, Van Dorsten P, Paul RH, Dombrowski MP, Roberts JM, McNellis D for the NICHD MFMU Network. The impact of digital cervial examination on expectantly managed preterm ruptured membranes. American Journal of Obstetrics & Gynecology, 183(4): 1003-1007, 2000.



4. Eric J. Knudtson, Kenneth Smith, Brian M. Mercer, Menachem Miodovnik, Gary R. Thurnau, Robert L. Goldenberg, Paul J. Meis, Atef H. Moawad, J. Peter Vandorsten, Yoram Sorokin et al. Serum homocysteine levels after preterm premature rupture of the membranes. American Journal of Obstetrics and Gynecology, 191(2): 537-541, 2004.



5. Hnat MD, Mercer BM, Miodovnik M, Thurnau G, Goldenberg R, Thom E, Meis P, Moawad A, Iams JD, Van Dorsten JP, Paul RH for the NICHD Maternal-Fetal Medicine Units Network. Perinatal outcomes in women with preterm rupture of membranes between 24-32 weeks and a history of vaginal bleeding. American Journal of Obstetrics & Gynecology, 193(1):164-168, 2005.



6. Mercer BM, Rabello YA, Thurnau GR, Miodovnik M, Goldenberg RL, Das AF, Meis PJ, Moawad AH, Iams JD, Van Dorsten JP, Dombrowski MP, Roberts JM, McNellis D for the NICHD Maternal-Fetal Medicine Units Network. The NICHD MFMU antibiotic treatment of pPROM study: Impact of initial amniotic fluid volume on pregnancy outcome. American Journal of Obstetrics and Gynecology, 194:438-445, 2006.

Presentations

1. Mercer B, Miodovnik M, Thurnau G, Goldenberg R, Das A, Merenstein G, Ramsey R, Rabello Y, Thom E, Roberts J, McNellis D and the NICHD MFMU Network. A multicenter randomized masked trial of antibiotic vs. placebo therapy after premature rupture of membranes. Presented at the 16th Annual Meeting of the Society of Perinatal Obstetricians, Kamuela, HI, February, 1996.



2. Thom E, Das A, Mercer B, McNellis D and the NICHD MFMU Network. Clinical trail monitorying in the face of changing clinical practice. Presented at the 17th Annual Meeting of the Society for Clinical Trials, Pittsburgh, PA, May 1996.



3. Das A, Thom E, Mercer B, McNellis D and the NICHD MFMU Network. Primary outcome varification in multicenter clinical trial. Presented at the 17th Annual Meeting of the Society for Clinical Trials, Pittsburgh, PA, May 1996.



4. Mercer B, for the NICHD MFMU Network. The NICHD-MFMU antibiotic treatment of pPROM Study: Multivariate analysis of factors associated with successful outcome after expectant management of pPROM. Presented at the 17th Annual Meeting of the Society of Perinatal Obstetricians, Anaheim, CA, January 1997.



5. Thurnau G, for the NICHD MFMU Network. The NICHD-MFMU Antibiotic Treatment of pPROM Study: Impact of initial amniotic fluid volume on pregnancy outcome. Presented at the 17th Annual Meeting of the Society of Perinatal Obstetricians, Anaheim, CA, January 1997.



6. Mercer B, for the NICHD MFMU Network. Maternal and neonatal plasma cytokine levels and perinatal morbidity after preterm PROM. Presented at the 44th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 1997.



7. Mercer B, for the NICHD MMU Network. Maternal and neonatal circulating ICAM-1 for the prediction of perinatal morbidity after preterm PROM. Presented at the 44th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 1997.



8. Beazley D, for the NICHD MFMU Network. Impact of amnionitis and antepartum antibiotic treatment on neonatal outcome after pPROM. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



9. How H, for the NICHD MFMU Network. The accuracy of vaginal pool fetal pulmonary maturity testing in gestation age of less than 31 weeks. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



10. Mercer BM, for the NICHD MFMU Network. Accuracy of ultrasound in the prediction of birthweight. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



11. Goldenberg R, for the NICHD MFMU Network. Serum ferritin, PROM and pregnancy outcome. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



12. Miodovnik M, for the NICHD MFMU Network. Risk factors associated with preterm premature rupture of the membranes. Presented at the 18th Annual Meeting of the Society of Perinatal Obstetricians, Miami, FL, February 1998.



13. Rosen B, for the NICHD MFMU Network. Antenatal markers of neonatal sepsis following preterm premature rupture of membranes. Presented at the 45th Annual Meeting of the Society for Gynecologic Investigation, March 1998.



14. McKinney ET, for the NICHD MFMU Network. Expectant management of pPROM: The relationship between cord blood gases and chorioamnionitis. Presented at the 19th Annual Meeting of the Society of Maternal-Fetal Medicine, San Francisco, CA, January 1999.



15. Alexander J, for the NICHD MFMU Network. The impact of digital cervical examination on expectantly managed preterm ruptured membranes. Presented at the 19th Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, January 1999.



16. How H, for the NICHD MFMU Network. Neonatal outcome following preterm premature rupture of membranes: indicated compared to spontaneous delivery. Presented at the 46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, GA, March 1999.



17. Hnat M, for the NICHD MFMU Network. Preterm rupture of membranes at 24-32 weeks: recent vaginal bleeding and perinatal outcome. Presented at the 22nd Annual Meeting of the Society for Maternal Fetal Medicine, New Orleans, LA, January 2002.



18. Hollier LM, for the NICHD MFMU Network. Eleveated cord blood erythropoietin is associated wiht infection in the neonate. Presented at eh 49th Annual Meeting fo the Society for Gynecologic Investigation, Los Angeles, CA,March 2002.



19. Hollier LM, for the NICHD MFMU Network. The impact of maternal antibiotics for preterm premature rupture of membranes on neonatal bacterial flora. Presented at the 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, March 2002.



20. Mertz H, for the NICHD MFMU Network. Associated factors for early preterm premature rupture of the membranes. Presented at the 49th Annual Meeting of the Society for Gynecologic Investigation, Los Angeles, CA, March 2002.



21. Knudtson E, for the NICHD MFMU NEtwork. Serum homocysteine (HC) levels and risk of pPROM. Presented at the 23rd Annual Meeting of the Society for Maternal Fetal Medicine, San Francisco, CA, February 2003.



22. Ramsey P, ofr the NICHD MFMU Network. Preterm premature rupture of membranes (pPROM): Latency and neonatal outcome. Presented at the 23rd Annual Meeting of the Society for Maternal Fetal Medicine, San Fancisco, Ca, February 2003.



23. Simhan H, for the NICHD MFMU Network. The MFMU PROM study: Maternal and neonatal cytokines, histologic findings and neonatal morbidity. Presented at the 24th Annual Meeting of the Society for the Maternal Fetal Medicine, New Orleans, LA, February 2004.



24. Simhan H, for the NICHD MFMU Network. The MFMU PROM study: The relationship of maternal plasma cytokine concentrations and antibiotics with latency and histologic chorioamnionitis. Presented at the 24th Annual Meeting of the Society for the Maternal Fetal Medicine, New Orleans, LA, February 2004.