| Medical Therapy
of Prostatic Symptoms (MTOPS) is a clinical research study sponsored by
the National Institutes of Health (NIH).
The study will test whether the oral drugs finasteride
(Proscar©)
and doxazosin (Cardura©),
alone or together, can further delay or prevent further prostate growth
in men with Benign Prostatic Hyperplasia(BPH).
MTOPS is the largest
and longest study to test whether the drugs can stop noncancerous prostate
growth. Seventeen U.S. medical centers
recruited 2931 men diagnosed with symptomatic BPH between December 1995
and March 1998. The study doctors will continue to follow these men
through November 2001 on a quarterly basis. In addition to the clinical
progression of BPH, MTOPS will include evaluations of prostate volume by
ultrasound, prostate histopathobiology, quality of life and urodynamics.
Funding by NIDDK (UO1-DK-46472),
1992-2002; IND 43,564.
|
Recruitment was completed in March 1998 with 2931 patients enrolled.