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MTOPS TIMETABLE
(AS OF 4/21/98)

PHASE DATES     TIME  
(in years)
PILOT:
Protocol Development
10/92 - 11/93
1.17
Randomization
12/93 - 11/94
1.00
Follow-up 
12/93 - 01/95
1.20
Close-out/Analysis
02/95 - 03/95
0.17
FULL-SCALE:
Transition
04/95 - 11/95
0.67
Randomization
12/95 - 03/98
2.33
Follow-up*
12/95 - 11/01
6.00
Close-out/Analysis
12/01 - 03/02
0.33
*Participants randomized during the pilot phase at clinical centers participating in the full-scale trial continue to be followed in the full-scale trial; potential average follow-up of 7.5 years (range 7 to 8 years).